Rodrigo Pires dos Santos, MD, PhD, of the Hospital Infection Control Committee at the Hospital de ClÃnicas de Porto Alegre in Porto Alegre, Brazil, and colleagues, sought to evaluate the impact of ertapenem use in Pseudomonas aeruginosa carbapenem resistance, taking into account the volume of antimicrobial consumption, the consumption by the entire hospital of alcohol-based antiseptic handrub, and the density rate of invasive practices.
In this before-and-after trial in a tertiary-care university hospital in southern Brazil, the researchers evaluated Pseudomonas aeruginosa resistance rates through three study periods: period 1, before ertapenem use (17 months); period 2, during ertapenem use (33 months); and period 3, after exclusion of ertapenem (15 months). Ertapenem was first added to the hospital formulary in June 2006 and it was excluded in February 2009.
The researchers report that following introduction of ertapenem, there was a significant decrease in median consumption of imipenem or meropenem, from 2.6 to 2.2 defined daily doses (DDDs) per 100 patient-days, as well as an increase in the use of these medications after ertapenem exclusion, from 2.2 to 3.3 DDDs per 100 patient-days, by segmented regression analysis. There was no difference in the incidence density of carbapenem-resistant P. aeruginosa infection related to ertapenem use throughout the study periods; however, by multiple regression analysis, the reduction in the rate of carbapenem-resistant P. aeruginosa infection correlated significantly with the increase in the volume of alcohol used as hand sanitizer, which was from 660.7 mL per 100 patient-days in period 1 to 2,955.1 mL per 100 patient-days in period 3 (). Ertapenem use did not impact the rate of carbapenem-resistant P. aeruginosa infection.
Pires dos Santos, et al. conclude that use of alcohol-based hand sanitizer, rather than ertapenem, was associated with a reduction in the rates of carbapenem-resistant P. aeruginosa infection. They add that measures to reduce resistance must include factors other than just antimicrobial stewardship programs alone.
Reference: Pires dos Santos R, et al. Hand Hygiene, and Not Ertapenem Use, Contributed to Reduction of Carbapenem-Resistant Pseudomonas aeruginosa Rates. Infect Control Hosp Epidem. Vol. 32, No. 6, June 2011.
The Guardians of Animal Health: Who Are Veterinary Infection Preventionists?
March 21st 2025Veterinary infection control experts Leslie Kollmann, BS, AAS, CVT, CIC, Denise Waiting, LVT, and Leslie Landis, LVT, BS, discuss challenges, zoonotic disease risks, and the importance of education, collaboration, and resource development in animal care facilities.
The Latest on CLABSIs and CAUTIs: Evidence-Based Approaches for Infection Prevention
February 27th 2025Health care–associated infections like CLABSIs and CAUTIs threaten patient safety. Learn evidence-based strategies, new technologies, and prevention protocols to reduce these infections and improve outcomes.
Resilience and Innovation: The Pivotal Contributions of Black Americans to Health Care and Medicine
February 24th 2025During Black History Month, we honor the resilience and contributions of Black medical professionals in health care. Despite barriers, they have led transformative changes, advocating for equitable access and medical excellence. Recognizing their impact ensures a more inclusive health care future for all.
Glove Usage Guideline: From The Joint Commission, CDC, and World Health Organization
February 17th 2025Proper glove use is crucial in health care settings to prevent infections. Guidelines from TJC, CDC, and WHO stress correct selection, usage, and disposal to minimize health care–associated infections (HAIs) and cross-contamination risks. Infection preventionists (IPs) play a key role in educating staff, enforcing compliance, and improving patient safety through standardized glove practices.