News
ICViewExpert PerspectivesMedical World NewsPathogen PlaybookVideosWebinars
Conference CoverageConference ListingAPIC Chapters
Infection Control TodaySupplements And Featured Publications
CME/CEEditorial Advisory BoardJob BoardPartnersSponsoredWhitepapers
Subscribe
Educator of the Year Official Rules2024 Educator of the Year Winner2023 Educator of the Year WinnerEducator of the Year
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
Spotlight -
  • IC Trends
  • Bug of the Month
  • Featured Articles
  • Featured Columns
  • Pathogen Playbook
Advanced TechnologyAdvanced TechnologyAdvanced Technology
Bug of the Month
COVID-19
Environmental ServicesEnvironmental Services
HAIs
Hand Hygiene
IC Trends
Long-Term CareLong-Term Care
Operating Room
Personal Protective EquipmentPersonal Protective Equipment
Policy
PreventionPreventionPreventionPrevention
Sterile ProcessingSterile Processing
Surface Disinfection
Vascular Access
    • News
    • Subscribe
Advertisement

Coat of Proteins Makes Viruses More Infectious and Links Them to Alzheimer's Disease

May 28, 2019
Article

New research from Stockholm University and Karolinska Institutet shows that viruses interact with proteins in the biological fluids of their host which results in a layer of proteins on the viral surface. This coat of proteins makes the virus more infectious and facilitates the formation of plaques characteristic of neurodegenerative diseases such as Alzheimer's disease.

Are viruses dead or alive? Well... both. Viruses can only reproduce inside living cells and exploit the cellular machinery of their host to their benefit. However, before entering a host cell, viruses are just nanometer-sized particles, very similar to artificial nanoparticles used in medical applications for diagnosis and therapy. Scientists from Stockholm University and Karolinska Institutet have found that viruses and nanoparticles share another important property; they both become covered by a layer of proteins when they encounter the biological fluids of their host before they find their target cell. This layer of proteins on the surface influence their biological activity significantly.

"Imagine a tennis ball falling into a bowl of milk and cereals. The ball is immediately covered by the sticky particles in the mix and they remain on the ball when you take it out of the bowl. The same thing happens when a virus gets in contact with blood or lung fluids that contain thousands of proteins. Many of these proteins immediately stick to the viral surface forming a so-called protein corona," says Kariem Ezzat of Stockholm University and Karolinska Institutet.

Ezzat and his colleagues studied the protein corona of respiratory syncytial virus (RSV) in different biological fluids. RSV is the most common cause of acute lower respiratory tract infections in young children worldwide, leading up to 34 million cases and 196,000 fatalities each year. "The protein corona signature of RSV in the blood is very different from that in lung fluids. It is also different between humans and other species such as rhesus macaque monkeys, which also can be infected with RSV," Ezzat says. "The virus remains unchanged on the genetic level. It just acquires different identities by accumulating different protein coronae on its surface depending on its environment. This makes it possible for the virus to use extracellular host factors for its benefit, and we've shown that many of these different coronae make RSV more infectious."

The researchers from Stockholm University and Karolinska Institutet have also found that viruses such as RSV and herpes simplex virus type 1 (HSV-1) can bind a special class of proteins called amyloid proteins. Amyloid proteins aggregate into plaques that play a part in Alzheimer's disease where they lead to neuronal cell death. The mechanism behind the connection between viruses and amyloid plaques has been hard to find until now, but Kariem Ezzat and his colleagues found that HSV-1 is able to accelerate the transformation of soluble amyloid proteins into thread-like structures that constitute the amyloid plaques. In animal models of Alzheimer's disease, they saw that mice developed the disease within 48 hours of infection in the brain. In absence of an HSV-1 infection the process normally takes several months.

"The novel mechanisms described in our paper can have an impact not only on understanding new factors determining how infectious a virus is, but also on devising new ways to design vaccines. In addition, describing a physical mechanism that links viral and amyloid causes of disease adds weight to the increasing research interest in the role of microbes in neurodegenerative disorders such as Alzheimer's disease and opens up new avenues for treatments," Ezzat says.

Source: Stockholm University

Recent Videos
Jordan Bastian, MPH, CIC, at APIC25
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Pathogen Playbook Presenter: Sharon Ward-Fore, BS, MS, MT(ASCP), CIC, FAPIC
Related Content

Washing hands at a sink  (Adobe Stock 1298928756)

A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings

Kerri Simone, MPH, CIC;Alexander O’Flaherty Linehan ;Will Zacamy
July 9th 2025
Article

Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.


Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.


A Profession Without a Path, Part 2

Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers

Shahbaz Salehi, MD, MPH, MSHIA;Anna Arifin, MD, MBA, MT, CIC
July 4th 2025
Article

Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.


Stretcher and HAIs  (Image courtesy of author through AI)

How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels

Donald Sipp, MBA, RESE, CHESP, CHTI-2, CMIP, PMP
July 3rd 2025
Article

Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.

Related Content

Washing hands at a sink  (Adobe Stock 1298928756)

A Helping Hand: Innovative Approaches to Expanding Hand Hygiene Programs in Acute Care Settings

Kerri Simone, MPH, CIC;Alexander O’Flaherty Linehan ;Will Zacamy
July 9th 2025
Article

Who knew candy, UV lights, and a college kid in scrubs could double hand hygiene adherence? A Pennsylvania hospital’s creative shake-up of its infection prevention program shows that sometimes it takes more than soap to get hands clean—and keep them that way.


Cori L. Ofstead, MSPH; Brandon M. Gantt, MHA, CRCST, CHL, CER, LSSGBH; and Jill E. Holdsworth, MS, CIC, FAPIC, NREMT, CRCST, CHL

Lumens 2.0 Study Results: Borescopes Reveal Hidden Challenges of Cleaning Lumened Surgical Instruments

Tori Whitacre Martonicz
July 8th 2025
Article

A groundbreaking study presented at HSPA25 and APIC25 exposed hidden contamination lurking inside orthopedic and neurosurgical instruments—even after cleaning. The Lumens 2.0 research highlights why infection prevention must look deeper than surface-level protocols.


Certification Board of Infection Control and Epidemiology (CBIC) logo  (Logo credit to CBIC)

CBIC Seeks Input for Job Analysis Survey for the a-IPC Certification

Infection Control Today® Editorial Staff
July 8th 2025
Article

The Certification Board of Infection Control and Epidemiology (CBIC) is calling on infection prevention professionals to help shape the future of the a-IPC exam through a vital new job analysis survey.


The Clean Bite

Why You Should Always Ask About Sterilization at the Dentist

Sherrie Busby, EDDA, CDSO, CDIPC
July 7th 2025
Article

Patients rarely question sterilization protocols at the dentist, yet it is essential for safety. The Clean Bite explores why asking matters, what to look for, and how to start the conversation confidently.


A Profession Without a Path, Part 2

Broadening the Path: Diverse Educational Routes Into Infection Prevention Careers

Shahbaz Salehi, MD, MPH, MSHIA;Anna Arifin, MD, MBA, MT, CIC
July 4th 2025
Article

Once dominated by nurses, infection prevention now welcomes professionals from public health, lab science, and respiratory therapy—each bringing unique expertise that strengthens patient safety and IPC programs.


Stretcher and HAIs  (Image courtesy of author through AI)

How Contaminated Is Your Stretcher? The Hidden Risks on Hospital Wheels

Donald Sipp, MBA, RESE, CHESP, CHTI-2, CMIP, PMP
July 3rd 2025
Article

Despite routine disinfection, hospital surfaces, such as stretchers, remain reservoirs for harmful microbes, according to several recent studies. From high-touch areas to damaged mattresses and the effectiveness of antimicrobial coatings, researchers continue to uncover persistent risks in environmental hygiene, highlighting the critical need for innovative, continuous disinfection strategies in health care settings.

Advertise
About Us
Editorial Board
Contact Us
Job Board
Terms and Conditions
Privacy
Do Not Sell My Personal Information
Contact Info

2 Commerce Drive
Cranbury, NJ 08512

609-716-7777

© 2025 MJH Life Sciences

All rights reserved.
Home
About Us
News