Hypothermia Does Not Increase Infection Risk in Patients with Digestive Tract Decontamination
Hypothermia may improve outcome in patients after traumatic brain injury, especially when hypothermia is maintained for more than 48 hours. In the acute phase, patients with severe brain injury are more vulnerable to infections. Prolonged hypothermic treatment may further enhance the risk of infection. Selective decontamination of the digestive tract (SDD) reduces the risk of respiratory tract infections.
Marlijn Kamps, of the Department of Intensive Care at Radboud University Nijmegen Medical Centre in Nijmegen, The Netherlands, and colleagues, sought to investigate the incidence of infections in patients treated with hypothermia and normothermia while receiving SDD.
In this retrospective case control study, 35 patients treated with prolonged hypothermia (cases) were identified and 169 patients with severe brain injury were included (controls). Propensity score matching was performed to correct for differences in baseline characteristics and clinical parameters. Primary outcome was the incidence of infection. The secondary endpoints were the micro-organisms found in the surveillance cultures and infection. In addition, a number of clinical characteristics were assessed.
The researchers report that the demographic and clinical data indicated that the cases and controls were well matched. The overall risk of infection during ICU stay was 20 percent in the hypothermia groups versus 34.4 percent in the normothermia group (p=0.388). Pneumonia was diagnosed in 11.4 percent of patients in both groups (p=1.000). The incidence of meningitis, wound infection, bacteremia, and urinary tract infection was low and comparable between the groups. SDD surveillance cultures indicated a higher colonization with gram-negative bacteria in the rectal samples of the hypothermia patients.
Thee researchers conclude that hypothermia does not increase the risk of infection in patients treated with SDD. Their research was published in Critical Care.
Reference: Kamps M, Bisschops L, van der Hoeven JG and Hoedemaekers CWE. Hypothermia does not increase the risk of infection: a case control study. Critical Care 2011, 15:R48doi:10.1186/cc10012
Back to Basics: Hospital Restores Catheter-Associated UTI Rates to Prepandemic Baseline
June 16th 2025A 758-bed quaternary medical center slashed catheter-associated urinary tract infections (CAUTIs) by 45% over 2 years, proving that disciplined adherence to fundamental prevention steps, not expensive add-ons, can reverse the pandemic-era spike in device-related harm.
Beyond the Surface: Tackling the Sterilization Challenges of Flexible Endoscopes
May 26th 2025Flexible endoscopes revolutionized modern medicine—but their complex design poses persistent sterilization challenges. With mounting infection risks and emerging innovations, experts are rethinking how to clean and safeguard one of health care’s most indispensable tools.
Silent Saboteurs: Managing Endotoxins for Sepsis-Free Sterilization
Invisible yet deadly, endotoxins evade traditional sterilization methods, posing significant risks during routine surgeries. Understanding and addressing their threat is critical for patient safety.
