Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli cause up to 10 percent of catheter-associated urinary tract infections (CAUTI). Spadafino, et al. (2014) report changes in ESBL prevalence among CAUTIs in an adult acute-care hospital from 2006-2012 and describe factors associated ESBL-production among E. coli CAUTI.
Data on patients discharged from a 647-bed tertiary/quaternary care hospital (2006-2012), a 221-bed community hospital (2007-2012), and a 914-bed tertiary/quaternary care hospital (2008) were obtained retrospectively from an electronic database (N=415,430 discharges). Infections were identified using a previously validated electronic algorithm. Information on medical conditions and treatments were collected from electronic health records and discharge billing codes. A case-control design was used to determine factors associated with having a CAUTI caused by an ESBL-producing E. coli versus a non-ESBL-producing E. coli. Changes in yearly proportion of ESBL E. coli CAUTI at the 647-bed tertiary/quaternary care hospital were evaluated. ESBL increased from 4% in 2006 to 14% in 2012, peaking at 18% in 2009. Prior antibiotic treatment and urinary tract disease significantly increased odds of ESBL.
This study provides evidence that treatment with beta-lactam and non-beta-lactam antibiotics is a risk factor for acquiring ESBL-producing E. coli CAUTI, and the prevalence of this organism may be increasing in acute-care hospitals. The research was published in Antimicrobial Resistance and Infection Control.
Spadafino JT, Cohen B, Liu J and Larson E. Temporal trends and risk factors for extended-spectrum beta-lactamase-producing Escherichia coli in adults with catheter-associated urinary tract infections. Antimicrobial Resistance and Infection Control 2014, 3:599 doi:10.1186/s13756-014-0039-y
Long COVID: Urgent Findings, Including Brain Alterations, Call for Renewed Public Health Focus
October 21st 2024New research highlights long COVID’s global impact, cognitive decline, and societal consequences, urging renewed focus on prevention, including vaccination, mask use, and better air quality.
Health Care-Associated Burkholderia multivorans Infections Traced to Contaminated Ice Machines
October 14th 2024Contaminated ice machines caused Burkholderia multivorans infections at hospitals in California and Colorado. Health officials recommend stopping ice machine use during clinical care to prevent further outbreaks.
Strengthening Defenses: Integrating Infection Control With Antimicrobial Stewardship
October 11th 2024Use this handout to explain the basics of why infection prevention and control and antimicrobial stewardship are essential and how the 2 fields must have a unified approach to patient and staff safety
Blood Product Overtransfusion Is a Global Issue: Here Are 5 Reasons the Practice Must Change
October 9th 2024If a patient receives treatment or therapy that they do not need, it can cause unnecessary harm. This is true for medications, surgeries, and medical procedures, especially blood transfusions.