Researchers at the University of Michigan Health System are helping to quell parents worry about why infants seem to get sick so often.
Newborns and infants are more prone to viral infections. A U-M study shows this sensitivity is due in part to age-dependent suppression of natural killer cell production.
Researchers at the University of Michigan Health System are helping to quell parents worry about why infants seem to get sick so often.
Its been believed that, like walking and talking, fighting viral infections is something children will develop when they get older. But a U-M study suggests the natural ability to fight infection is there early on.
Scientists learned key cell signals inhibit the growth of essential immune cells early in life. Blocking this signaling could lead to improving an infants response to infection, according to the study published online ahead of print in Nature Immunity.
What happens at early age is that natural killer cells, like many other immune cells, do not complete their functional maturation until adulthood, says study senior author Yasmina Laouar, PhD, assistant professor in the U-M Department of Microbiology and Immunology. During this time we are left with an immature immune system that cannot protect us against infections, the reason why newborns and infants are more prone to infection, she says.
There is a large gap in understanding infant immunity, specifically why the natural killer cell responses are deficient. The study by immunologists at the U-M demonstrates the role of a cell called transforming growth factor beta that can explain why.
The study showed the production of natural killer cells is controlled by TGF-, which is produced in the bone marrow. In infant mice, the maturation of natural killer cells progressed faster in the absence of TGF- signaling.
By adulthood, mice had 10 times more mature natural killer cells if TGF- signaling was blocked.
Our overall goal was to determine the factors that constraint the production and maturation of natural killer cells early in life, says Laouar. To our surprise, we discovered that natural killer cells can complete maturation as early as 10 days of age if TGF- signaling is blocked.
 Additional authors include Jeffrey P. Marcoe, James R. Lin, Keri L. Schaubert, Marsel Matka, Alexandra L. McCubbrey, Alexander R. Farr, all of the U-M Medical School, and Silvia M. Vidal and Nassima Fodil-Cornu, of McGill University, Montreal.
Reference: TGF- is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nature Immunity, doi: 10.1038/ni.2388.
From the Derby to the Decontam Room: Leadership Lessons for Sterile Processing
April 27th 2025Elizabeth (Betty) Casey, MSN, RN, CNOR, CRCST, CHL, is the SVP of Operations and Chief Nursing Officer at Surgical Solutions in Overland, Kansas. This SPD leader reframes preparation, unpredictability, and teamwork by comparing surgical services to the Kentucky Derby to reenergize sterile processing professionals and inspire systemic change.
Show, Tell, Teach: Elevating EVS Training Through Cognitive Science and Performance Coaching
April 25th 2025Training EVS workers for hygiene excellence demands more than manuals—it requires active engagement, motor skills coaching, and teach-back techniques to reduce HAIs and improve patient outcomes.
The Rise of Disposable Products in Health Care Cleaning and Linens
April 25th 2025Health care-associated infections are driving a shift toward disposable microfiber cloths, mop pads, and curtains—offering infection prevention, regulatory compliance, and operational efficiency in one-time-use solutions.
Phage Therapy’s Future: Tackling Antimicrobial Resistance With Precision Viruses
April 24th 2025Bacteriophage therapy presents a promising alternative to antibiotics, especially as antimicrobial resistance continues to increase. Dr. Ran Nir-Paz discusses its potential, challenges, and future applications in this technology.